Evolutionarily new sequences expressed in tumors

doi:10.1186/1750-9378-1-8

Infectious Agents and Cancer

Volume 1

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Kozlov AP
Galachyants YP
Dukhovlinov IV
Samusik NA
Baranova AV
Polev DE
Krukovskaya LL

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Kozlov AP
Galachyants YP
Dukhovlinov IV
Samusik NA
Baranova AV
Polev DE
Krukovskaya LL
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Research article

Evolutionarily new sequences expressed in tumors

Andrei P Kozlov¹ , Yuri P Galachyants¹ , Ilya V Dukhovlinov¹ , Nickolai A Samusik¹ , Ancha V Baranova¹^,2 , Dmitry E Polev¹ and Larisa L Krukovskaya¹

¹The Biomedical Center, 8 Vyborgskaya St., St.Petersburg, 194044, Russia

²Center for the Study of Genomics in Liver Disearses, Molecular and Microbiology Department, George Mason University, Fairfax, USA

author email corresponding author email

Infectious Agents and Cancer 2006, 1:8doi:10.1186/1750-9378-1-8


Published:	25 December 2006

Abstract

Background

Earlier we suggested the concept of the positive evolutionary role of tumors. According to this concept, tumors provide conditions for the expression of evolutionarily new and/or sleeping genes in their cells. Thus, tumors are considered as evolutionary proving ground or reservoir of expression. To support this concept we have previously characterized in silico and experimentally a new class of human tumor-related transcribed sequences.

Results

In this article we describe results of further studies of previously described tumor-related sequences. The results of molecular phylogeny studies, Southern hybridization experiments and computational comparison with genomes of other species are presented.

Conclusion

These results suggest that these previously described tumor-related human transcripts are also relatively evolutionarily new.