|
HPV genotyping by DNA Sequencing v. Digene HC2 Test |
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| PCR/DNA Sequencing |
Test Results by Digene HC2 |
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|
|
|
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| Type Positive Cases |
Prevalence (%) |
High-risk+ |
Negative |
|
| 16 |
29 |
(27.2) |
11 |
18 |
| 56 |
9 |
(8.5) |
9 |
0 |
| 31 |
7 |
(6.5) |
5 |
2 |
| 6 |
6 |
(5.6) |
2 |
4 |
| 18 |
6 |
(5.6) |
6 |
0 |
| 54 |
6 |
(5.6) |
3 |
3 |
| 58 |
6 |
(5.6) |
5 |
1 |
| 66 |
6 |
(5.6) |
6 |
0 |
| 59 |
4 |
(3.7) |
4 |
0 |
| 45 |
3 |
(2.8) |
2 |
1 |
| 83 |
3 |
(2.8) |
2 |
1 |
| 32 |
2 |
(1.9) |
0 |
2 |
| 35 |
2 |
(1.9) |
1 |
1 |
| 39 |
2 |
(1.9) |
2 |
0 |
| 40 |
2 |
(1.9) |
0 |
2 |
| 52 |
2 |
(1.9) |
1 |
1 |
| 33 |
1 |
(0.9) |
1 |
0 |
| 53 |
1 |
(0.9) |
1 |
0 |
| 62 |
1 |
(0.9) |
1 |
0 |
| 68 |
1 |
(0.9) |
1 |
0 |
| 70 |
1 |
(0.9) |
1 |
0 |
| 72 |
1 |
(0.9) |
0 |
1 |
| 73 |
1 |
(0.9) |
0 |
1 |
| M16 |
1 |
(0.9) |
1 |
0 |
| M 16, 18 |
1 |
(0.9) |
1 |
0 |
| M others |
3 |
(2.9) |
1 |
2 |
| Total |
107 |
(100) |
67 |
40 |
|
|
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| HC2 HPV detection rate = 67/107 = 62.6% |
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| Samples |
513 |
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| %HPV+ 20.9 |
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|
M16 = mixed infection with HPV 16 identified by type-specific sequencing primer. M 16, 18 = mixed infection with HPV 16 and HPV 18 identified by type-specific sequencing primers. M others = mixed infections by HPV types which cannot be sequenced with type-specific primers for HPV 6, 11, 16 or 18. Digene High-risk + includes those cases reported as positive for both High-risk and Low-risk HPV types. The underlined HPV genotypes are included in the "High-risk" Digene HC2 cocktail probe. | ||||
Lee et al. Infectious Agents and Cancer 2007 2:11 doi:10.1186/1750-9378-2-11 |
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