Table 1

Cytological and histological criteria used for diagnosis of cervical lesions

Lesions

Criteria for diagnosis

Ref.


Cytologic HPV

Koilocytic atypia

Multinucleation (frequently binucleation)

Dyskeratosis

Parakeratosis

34

ASCUS

Nuclear enlargement approximately twice the size of an immature squamous metaplastic cell

Slight increase in nucleo-cytoplasmic ratio

Nuclear chromatin clumping

Variation in nuclear size and shape including mild hyperchromasia, binucleation, and mild irregularity in the nuclear membranes

35, 36

AGCUS

Nuclear enlargement approximately twice the size of an endocervical cell.

Nuclear pseudostratification

Mild hyperchromasia

37

Discriminating AGUS from neoplastic endocervical cells

Presence of normal ECCs, singly or in sheets

Absence of necrosis

Absence of papillary groups

Mild anisonucleosis

Marked chromatin distribution

37

EGD

Nuclei not cytologically malignant

Nuclear hyperchromasia and pseudostratification

Low mitotic figures

Absence of papillary formation and cribriform pattern

38

Histologic HPV

Koilocytic atypia: 4 points

Binucleation: 2 points

Dyskeratosis: one point

Basal cell hyperplasia: one point

Papillomatosis: one point

Acanthosis: one point

34


Abd El All et al. Infectious Agents and Cancer 2007 2:12   doi:10.1186/1750-9378-2-12

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