Figure 4.

Experimental Cryptosporidium parvum infection of Dex-treated SCID mice: caecal region. (A) Polyp with areas of high-grade intraepithelial neoplasia (arrow 1) and intramucosal adenocarcinoma (arrow 2); (B) Abnormal nuclear changes consisting of prominent nucleoli and irregularly scattered chromatin; (C) Highly irregular glands, areas of loss of glandular differentiation. Presence of numerous parasites (arrow); (D) Presence of numerous parasites at different developmental stages in the intestinal epithelium (arrow). Hematoxylin & Eosin staining.