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Experimental infection of Dexamethasone-treated or untreated SCID mice infected with C. parvum or C. muris: Main clinical and histopathological data |
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| Groupa |
Mouse N° |
Day of euthanasia (post-infection) |
Oocysts/mg faeces at euthanasia |
Clinical manifestations |
Main histological changes |
|
|
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| P |
1 |
20 |
0 |
Occasional diarrhoea |
Undetected |
| 2 |
28 |
0 |
Lethargy |
Undetected |
|
| 3 |
28 |
1 |
None |
N.D. |
|
| 4 |
84 |
1 |
Occasional diarrhoea |
Undetected |
|
| 5 |
84 |
4 |
Occasional diarrhoea |
Undetected |
|
| 6 |
84 |
0 |
Occasional diarrhoea |
N.D. |
|
| Pdex |
7 |
20 |
29 |
Occasional diarrhoea |
Undetected |
| 8 |
28 |
102 |
Lethargy, ruffled coat |
Undetected |
|
| 9 |
28 |
95 |
Lethargy, ruffled coat |
N.D. |
|
| 10 |
46 |
1182 |
Lethargy, ruffled coat |
Polyps with areas of low-grade and high-grade intraepithelial neoplasia, and intramucosal adenocarcinoma at the ileocaecal region |
|
| 11 |
62 |
240 |
Lethargy, ruffled coat |
Polyps with areas of low-grade and high-grade intraepithelial neoplasia, and intramucosal adenocarcinoma at the ileocaecal region |
|
| 12 |
84 |
695 |
Lethargy, ruffled coat |
Polyps with areas of low-grade and high-grade intraepithelial neoplasia, and intramucosal adenocarcinoma at the ileocaecal region |
|
| M |
13 |
20 |
1078 |
None |
Stomach heavily infected mainly at the fundic region; dilated glands; hyperplasia |
| 14 |
20 |
407 |
None |
N.D. |
|
| 15 |
28 |
742 |
None |
Stomach heavily infected mainly at the fundic glands, hyperplasia |
|
| 16 |
84 |
4143 |
None |
Stomach heavily infected mainly at the fundic region; dilated glands; hyperplasia |
|
| 17 |
84 |
4920 |
None |
Stomach heavily infected |
|
| 18 |
84 |
5828 |
None |
None |
|
| Mdex |
19 |
20 |
1538 |
Occasional diarrhoea |
Stomach heavily infected; dilated glands |
| 20 |
20 |
166 |
Occasional diarrhoea |
N.D. |
|
| 21 |
27 |
1241 |
Occasional diarrhoea |
N.D. |
|
| 22 |
32 |
4155 |
Frequent diarrhoea, lethargy, ruffled coat |
Stomach heavily infected mainly at the fundic glands; hyperplasia |
|
| 23 |
46 |
900 |
Lethargy, ruffled coat |
Stomach heavily infected mainly at the fundic glands; hyperplasia |
|
| 24 |
84 |
2051 |
None |
Stomach heavily infected mainly at the fundic glands; hyperplasia; a little inflammation |
|
| C |
25 |
20 |
0 |
None |
Undetected |
| 26 |
67 |
0 |
Lethargy, ruffled coat |
Undetected |
|
| 27 |
84 |
0 |
None |
Undetected |
|
| Cdex |
28 |
20 |
0 |
None |
Undetected |
| 29 |
43 |
0 |
None |
Undetected |
|
| 30 |
84 |
0 |
None |
Undetected |
|
| Cdex2 |
31 |
54 |
0 |
None |
Undetected |
| 32 |
54 |
0 |
None |
Undetected |
|
| 33 |
54 |
0 |
None |
Undetected |
|
| 34 |
54 |
0 |
None |
Undetected |
|
| 35 |
54 |
0 |
None |
Undetected |
|
| 36 |
54 |
0 |
None |
Undetected |
|
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aExperimental groups were: P: C. parvum-infected SCID mice; PDex: C. parvum-infected Dex-treated SCID mice; M: C. muris-infected SCID mice; MDex: C. muris-infected Dex-treated SCID mice; C: Not infected SCID mice of control group inoculated with PBS; CDex: Not infected Dex-treated SCID mice of control group inoculated with PBS; CDex2: Not infected Dex-treated SCID mice that received an inoculum from which oocysts were previously removed by filtration; N.D.: Not done (These mice were not included in the histological examination). | |||||
Certad et al. Infectious Agents and Cancer 2007 2:22 doi:10.1186/1750-9378-2-22 |
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