Research article
HPV type infection in different anogenital sites among HIV-positive Brazilian women
1 Division of Clinical Immunology, University of São Paulo, São Paulo, Brazil
2 Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy
3 International Agency for Research on Cancer, Lyon, France
4 Department of Virology, Ludwig Institute for Cancer Research, São Paulo, Brazil
5 School of Medicine, Department of Pathology, University of São Paulo, São Paulo, Brazil
Infectious Agents and Cancer 2008, 3:5 doi:10.1186/1750-9378-3-5
Published: 14 March 2008Abstract
Objectives
To evaluate the prevalence of human papillomavirus (HPV) types, and risk factors for HPV positivity across cervix, vagina and anus, we conducted a study among 138 women with human immunodeficiency virus (HIV).
Goal
Compare the prevalence of different HPV types and the risk factors for HPV positivity in three sites.
Results
The most frequently detected HPV types in all sites were, in decreasing order, HPV16, 53, 18, 61 and 81. Agreement between the cervix and vagina was good (kappa 0.60 – 0.80) for HPV16 and 53 and excellent (Kappa > 0.80) for HPV18 and 61. HPV positivity was inversely associated with age for all combinations including the anal site.
Conclusion
In HIV positive women, HPV18 is the most spread HPV type found in combinations of anal and genital sites. The relationship of anal to genital infection has implications for the development of anal malignancies. Thus, the efficacy of the current HPV vaccine may be considered not only for the cervix, but also for prevention of HPV18 anal infection among immunossuppressed individuals.
