Table 2

Key clinical characteristics of the patients related to their serological response to HPV16 antigens

Variables

Anti-E and -L

Anti-E₄-E₆ and E₇

Anti L₁ and -L₂

+

-

Sign.

+

-

Sign.

+

-

Sign.

HPV DNA (%):

Positive 76

89.5

10.5

OR = 2.8 (0.8–9.9)

71.1

28.9

OR = 1.3 (0.4–3.7)

71.1

28.9

OR = 1.6 (0.6–4.6)

p = 0.136

p = 0.604

p = 0.350

Negative 20

75.0

25.0

65.0

35.0

60.0

40.0

HR-HPV (%)

Positive 66

87.9

12.1

OR = 1.4 (0.4–4.8)

68.2

31.8

OR = 0.8 (0.3–2.0)

69.7

30.3

OR = 1.1 (0.5–2.9)

p = 0.536

p = 0.608

p = 0.767

Negative 30

83.3

16.7

73.3

26.7

66.7

33.3

LR-HPV (%):

Positive 10

100

0.0

OR = NC

90.0

10.0

OR = 4.3 (0.5–30.0)

80.0

20.0

OR = 1.9 (0.4–9.7):

p = 0.348

p = 0.273

p = 0.720

Negative 86

84.9

15.1

67.4

32.6

67.4

32.6

Previous:

HPV (%):

Yes 19

94.7

5.3

OR = 2.8 (0.3–23.9);

89.5

10.5

OR = 4.8 (1.1–22.8)

73.7

26.3

OR = 0.9 (0.3–3.1);

p = 0.445

p = 0.046

p = 0.961

No 66

86.4

13.6

63.6

36.4

74.2

25.8

HIV-Status (%):

Negative 84

89.3

10.7

OR = 4.2(1.1–16.5)

71.4

28.6

OR = 1.8 (0.5–6.2)

72.6

27.4

OR = 3.7 (1.1–12.9)

p = 0.032

p = 0.355

p = 0.030

Positive 12

66.7

33.3

58.3

41.7

41.7

58.3

Smokers 9

66.6

33.3

55.6

44.4

33.3

66.7

Previous:

PAP (%):

Never 10

90.0

10.0

p = 0.793

70.0

30.0

p = 0.111

80.0

20.0

p = 0.445

Irregular 26

92.3

7.7

84.6

15.4

61.5

38.5

Regular (1–3 yrs) 49

85.7

14.3

61.2

38.8

75.5

24.5

Referral

PAP (%):

ASC-US 7

100

0.0

p = 0.431

85.7

14.3

p = 0.623

100

0.0

p = 0.094

LSIL 48

91.7

8.3

64.6

35.4

75.0

25.0

p = 0.031*

HSIL 16

81.3

18.7

68.8

31.2

56.3

43.7

Biopsy

Result (%):

Normal 1

100

0.0

0.0

100

100

0.0

HPV-NCIN 9

100

0.0

p = 0.262

66.7

33.3

p = 0.526

77.8

22.2

p = 0.564

CIN1 11

90.9

9.1

54.5

45.5

63.6

36.4

CIN2 14

92.9

7.1

71.4

28.6

85.7

14.3

CIN3 15

93.3

6.7

73.3

16.7

73.3

26.7

SCC 2

50.0

50.0

50.0

50.0

50.0

50.0

Genital

Warts (%):

Yes 20

95.0

5.0

OR = 3.3(0.4–27.7)

80.0

20.0

OR = 2.1 (0.6–7.0)

75.0

25.0

OR = 1.1 (0.4–3.7)

p = 0.437

p = 0.275

p = 0.801

No 61

85.2

14.8

65.6

34.4

72.1

27.9

Colposcopy (%):

Normal 2

100

0.0

100

0.0

0.0

100

Low-grade 27

96.3

3.74

p = 0.177

63.0

37.0

p = 0.668

85.2

14.8

p = 0.015

High-grade 28

77.8

22.2

72.2

27.8

61.1

28.9

NC, non-computable; ¹Contraception used until past; ²Contraception in current use; *For linear trend; HPV-NCIN, HPV infection without CIN....

Giorgi et al. Infectious Agents and Cancer 2008 3:9   doi:10.1186/1750-9378-3-9