This article is part of the supplement: Proceedings of the 11th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research
Oral presentation
HIV induces the expression of activation-induced cytidine deaminase (AICDA) in B cells through a direct interaction between virion-associated CD40L and CD40
Infectious Agents and Cancer 2009, 4(Suppl 2):O11 doi:10.1186/1750-9378-4-S2-O11
Published: 17 June 2009First paragraph (this article has no abstract)
NHL is a common AIDS-associated cancer. NHL is thought to occur due to errors in Class Switch Recombination (CSR) and Somatic Hypermutation (SHM); both of these events occur in Germinal Center (GC) B cells. Activation-Induced Cytidine deaminase (AICDA) is an enzyme required for both CSR and SHM. Since errors in both CSR and SHM lead to the seminal molecular lesions in NHL development, it is thought that AICDA plays a central role in the genesis of these cancers. It has been shown by us and others that several oncogenic viruses (EBV, HCV, HPV) can induce AICDA expression. We have also shown that AICDA expression in PBMC is elevated prior to AIDS-NHL diagnosis. Additionally, several studies have shown that exposure of B cells to HIV can result in their activation.