This article is part of the supplement: Proceedings of the 11th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research .

Oral presentation

High resolution profiling of DNA copy number and gene expression changes in AIDS-related lymphoma

KE Deffenbacher, Z Liu, J Iqbal, H Geng, K Fu and WC Chan

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA

corresponding author email

from 11th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research
Bethesda, MD, USA. 6–7 October 2008

Infectious Agents and Cancer 2009, 4(Suppl 2):O8doi:10.1186/1750-9378-4-S2-O8

Published:	17 June 2009

First paragraph (this article has no abstract)

The incidence of B cell non-Hodgkin lymphoma (NHL) is increased substantially in the HIV-1-infected immunosuppressed population. Clinically, AIDS-related lymphoma (ARL) is more aggressive and has a worse prognosis than in non-immunocompromised patients, though there has been significant improvement in the post-HAART era. While HIV-induced immunosuppression, chronic antigenic stimulation, and cytokine overproduction may contribute to differences in disease progression and outcome, distinct genetic changes in ARL may also mediate these effects. Chromosomal DNA copy number alterations are known to play a major role in lymphomagenesis and have been studied in non immunocompromised patients for some NHLs.