Table 2 |
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|
Three multinomial logistic regression models for association of classic Kaposi sarcoma (cKS) and KS-associated herpesvirus with aggregate exposures to plants, adjusted for core-model variables.* |
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|
cKS cases |
KSHV-negative controls |
KSHV + controls* |
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|
|
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|
Variables |
N |
OR* |
95% CI |
P |
N |
OR* |
95% CI |
P |
N |
|
|
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|
Cumulative plant exposure model |
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|
Lifetime contacts with 20 plants¶ |
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|
> 1262 |
19 |
0.93 |
0.35 - 2.44 |
201 |
1.73 |
0.78 - 3.83 |
16 |
||
|
281 - 1262 |
34 |
1.16 |
0.47 - 2.85 |
0.87† |
189 |
1.16 |
0.54 - 2.50 |
0.04† |
24 |
|
69 - 280 |
40 |
0.97 |
0.40 - 2.32 |
183 |
0.58 |
0.27 - 1.22 |
28 |
||
|
0 - 68 |
29 |
Ref |
179 |
Ref |
20 |
||||
|
Plant cluster model |
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|
Cluster C‡ |
4 |
0.72 |
0.19 - 2.80 |
0.64 |
41 |
1.17 |
0.42 - 3.28 |
0.76 |
6 |
|
Cluster B |
21 |
2.1 |
0.83 - 5.29 |
0.11 |
153 |
3.01 |
1.31 - 6.92 |
0.01 |
10 |
|
Cluster A |
97 |
Ref |
558 |
Ref |
72 |
||||
|
Plant factor model |
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|
Asteraceae factor |
|||||||||
|
> median |
56 |
1.12 |
0.58 - 2.19 |
0.73 |
390 |
1.19 |
0.68 - 2.07 |
0.55 |
43 |
|
≤ median |
66 |
Ref |
362 |
Ref |
45 |
||||
|
Euphorbia/Datura/Agave factor |
|||||||||
|
> median |
59 |
0.77 |
0.40 - 1.50 |
0.44 |
378 |
0.66 |
0.37 - 1.17 |
0.15 |
49 |
|
≤ median |
63 |
Ref |
374 |
Ref |
39 |
||||
|
Hypericum factor |
|||||||||
|
> median |
65 |
0.92 |
0.46 - 1.84 |
0.81 |
366 |
0.87 |
0.47 - 1.58 |
0.64 |
42 |
|
≤ median |
57 |
Ref |
386 |
Ref |
46 |
||||
|
Food/beverage/gladiolus factor |
|||||||||
|
> median |
61 |
1.23 |
0.58 - 2.60 |
0.58 |
395 |
1.51 |
0.79 - 2.89 |
0.21 |
40 |
|
≤ median |
61 |
Ref |
357 |
Ref |
48 |
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|
|
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|
* Odds ratios (OR) and confidence intervals (CI), with KSHV+ controls as referent group, are adjusted for the variables in each model, as well as those in the "core model" (Table 1). ¶ The 20 plants were: Agave americana (Agavaceae), Acanthus mollis (Acanthaceae), Ceratonia siliqua (Fabaceae), Chrozophora tinctoria (Euphorbiaceae), Cichorium intybus (Asteraceae), Datura stramonium (Solanaceae), Dittrichia (formerly Inula) viscosa (Asteraceae), Euphorbia characias (Euphorbiaceae), Euphorbia dendroides (Euphorbiaceae), Euphorbia rigida (Euphorbiaceae), Gladiolus communis o italicus (Iridaceae), Hieracium (Asteraceae), Hypericum hircinum (Clusiaceae), Hypericum perforatum guttiferae (Clusiaceae), Iris sisyrinchium (Iridaceae), Lupinus albus (Fabaceae), Matricaria chamomilla compositae (Asteraceae), Picris echioides (Asteraceae), Taraxacum officinale (Asteraceae), and Trigonella foenum-graecum (Fabraceae). † Ptrend values. ‡ Cluster C is numerous plant contacts including Hypericum and Euphorbia. Cluster B is numerous plant contacts other than Hypericum and Euphorbia. Cluster A is relatively few plant contacts. |
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|
Goedert et al. Infectious Agents and Cancer 2010 5:23 doi:10.1186/1750-9378-5-23 |
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