Table 6 |
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HAART and Incidence of Invasive Cervical Cancer |
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Author |
Outcome |
Design |
Results Comparison and reference groups |
Association measures and CI |
Conclusion |
|
|
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|
Intl Collaboration on HIV and Cancer 2000 |
Cases of ICC in multiple population studies |
Meta-analysis |
1997-1999 (post-HAART) vs. 1992-1996 (pre-HAART) |
Adj IR 2.1 vs. 1.1; RR 1.87 (99% CI 0.77 - 4.56) |
Higher incidence post HAART years, but not stats. significant |
|
Dorucci et al 2001 |
Cases of ICC in Italian HIV Seroconversion Study |
Prospective cohort/time-series analysis |
1996-1998 (post-HAART) vs. 1981-1995 (pre-HAART) |
IR 4.9 vs. 1.5; RH of Incidence 4.25 (0.8 - 28.24) |
Higher incidence post HAART years, but not stats. significant |
|
Clifford et al 2005 |
Cases of ICC from Swiss Cancer Registry |
AIDS-Cancer Match Study |
HAART vs. no HAART |
SIR 0 vs. SIR 11.4; RR not estimatable |
Unclear (incomplete reporting) |
|
Engels et al 2006 |
Cases of ICC in HIV/AIDS Cancer Match Study |
AIDS-Cancer Match Study |
1996-2002 (post-HAART) vs. 1990-1995 (pre-HAART) |
SIR 5.3 vs. SIR 4.2; RR pr year: 1.04 (95% CI: 0.94-1.15) |
Higher incidence post HAART years, but not stats. significant |
|
Biggar et al 2007 |
Cases of ICC in HIV/AIDS Cancer Match Study |
AIDS-Cancer Match Study |
1996-2002 (post-HART) vs. 1990-1995 (pre-HAART) |
IR 86.5 vs. 64.2; RR of Incidence 1.41 (95% CI 0.81-2.46) |
Higher incidence post HAART years, but not stats. significant |
|
Engels et al 2008 |
Cases of ICC in HIV/AIDS Cancer Match Study |
AIDS-Cancer Match Study |
1996-2002 (post-HAART) vs. 1991-1995 (pre-HAART) |
SIR 2.9 vs. 3.1; RR 0.8 (95% CI 0.3 - 2.0) |
Lower incidence post HAART years, but not stats. significant |
|
Dal Maso et al 2009 |
Cases of ICC in Italian Cancer Registries |
AIDS-Cancer Match study |
1997-2004 (post-HAART) vs. 1986-1996 (pre-HAART) |
SIR 41.5 vs. 51.0; RR not reported |
Lower incidence in post HAART years, but conclusion unclear (incomplete reporting) |
|
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Foot note to tables: Abbreviations: ASCUS = atypical squamous cells of undetermined significance CD4+ = CD4+ T lymphocyte count (cells/mm3) DHHS = U.S. Department of Health and Human Services HAART = Highly active antiretroviral therapy HERS = HIV Epidemiology Research Study HIV = Human Immunodeficiency Virus HPV = Human papillomavirus HR = Hazard ratio HSIL = high-grade squamous intraepithelial lesions ICC = Invasive cervical cancer LSIL = low-grade squamous intraepithelial lesions NRTI = Nucleoside reverse transcriptase inhibitor NNRTI = Non-nucleoside reverse transcriptase inhibitor NR = Not reported OR = Odds ratio Pap = Papanicolaou smear PI = Protease inhibitor RR = Relative risk (rate ratio) SIR = Standardized incidence ratio WIHS = Women's Interagency HIV Study |
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Bratcher and Sahasrabuddhe Infectious Agents and Cancer 2010 5:8 doi:10.1186/1750-9378-5-8 |
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