HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma
1 Department of Medicine, Division of Hematology and Oncology, University of California, San Diego, Room 2238, 3855 Health Sciences Drive, La Jolla, San Diego, CA 92093-0987, USA
2 Department of Medicine, Division of Infectious Diseases, University of California, San Diego, 150 West Washington St, San Diego, CA 92103, USA
Infectious Agents and Cancer 2012, 7:6 doi:10.1186/1750-9378-7-6Published: 15 March 2012
In this study 15 banked samples of HIV-related Non-Hodgkin's Lymphoma (NHL) cases were tested for HIV co-receptor usage and SDF1 3'A polymorphism. Reportable tropism from 9 plasma samples had 1 (11.1%) HIV case with CXCR4 and 8 (88.9%) with CCR5 usage, even though most of the cases occurred at a late stage of HIV (2/3 had CD4 counts below 200), where expected CXCR4 usage would be 60%. Based on the expected proportion of less than 50% CCR5 in chronically infected individuals, this would suggest that in NHL may be associated with CCR5 usage (P = 0.04).