Bovine papillomavirus on the scene of crime: is E5 oncogene the only guilty party?
Department of Veterinary medicine and Animal productions, University of Naples Federico II, Via F. Delpino, 1-80137, Naples, Italy
Infectious Agents and Cancer 2013, 8:26 doi:10.1186/1750-9378-8-26Published: 5 July 2013
Bovine papillomaviruses (BPVs) induce hyperplastic and tumoral lesions not only in cows but also in other different animal species. The transforming activity of BPVs is due to its major E5 oncogene. Recent studies have highlighted the role of E5 in cancer development but very little is known about E6 and E7 oncogenes. In this letter we argue for the need of investigating E6 as well as E7 to better understand the role of these two oncogenes during carcinogenesis.