HPV test is a virology test, not for predicting cancer (Sin Hang Lee, 19 August 2009)
Since Dr. Castle wrote this Commentary from an office in the authoritative National Cancer Institute of the United States (NCI) and the Commentary was published in a peer-reviewed international scientific journal, his opinions will unfortunately influence many health care policy makers whose decisions will in turn affect the welfare of many women worldwide. The undersigned felt obligated to comment on this Commentary.
Under an academic title, the Commentary promotes a generation of less specific HPV tests which may refer more women to unnecessary colposcopic biopsies than the Digene hc2 HPV test due to cross-reactivity with non-target HPV types. The Commentary endorsed these HPV tests “despite the cross-reactivity to these weakly carcinogenic or non-carcinogenic HPV...
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Comment on: Castle Infectious Agents and Cancer, 4:7
Please investigate cytomegalovirus (Carol Thompson, 15 February 2009)
Please investigate cytomegalovirus before concluding that smoking is the cause. For socioeconomic reasons, smokers are more likely to have been infected by this virus, which is known to have powerful immunosuppressive effects.
Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination--an impact of immunosenescence. P Trzonkowski, J Myśliwska, E Szmit, J Wieckiewicz, K Lukaszuk, LB Brydak, M Machała, A Myśliwski. Vaccine 2003 Sep 8;21(25-26):3826-3836. "Non-responders of both ages we characterised by higher levels of anti-CMV IgG and higher percentages of CD57+CD28- lymphocytes (known to be associated with CMV carrier status) together with increased concentrations of...
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Comment on: Giorgi et al. Infectious Agents and Cancer, 3:9
Cancer of Uterine Cervix and Oncological Terrain with Inherited Oncological Real Risk. (Sergio Stagnaro, 11 February 2009)
Editors,I consider artiche conclusion unfortunately erroneously incomplete: The strong association found between HPV infection, specifically types 16 and 18 and cancer of the uterine cervix in Zaragoza, Spain, stresses the importance of ongoing efforts to institute a vaccine program with recently approved HPV vaccines in order to prevent cervical cancer in this population. As a matter of facts, cervix cancer involves exclusively women with Oncological Terrain “and” Inherited Oncolgical Real Risk of cervix. If we administer anti-HPV Vaccine to women without such as predisposition, we lose money, time and energy uselessly(1-10).1) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it...
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Comment on: Bernal et al. Infectious Agents and Cancer, 3:8
Seeking comments on "Human Mammary Tumor Virus" (Brian Foley, 16 November 2006)
There are now dozens of GenBank DNA sequence entries for "Human Mammary Tunor Virus", such as the ones with accession numbers DQ910870 and AF248269. There are also many more, identified as "Mouse Mammary Tumor Virus" from human cancer tissue. Also AF513916 "human betaretrovirus". As well as at least one paper linking the geographical distribution of mice to human breast cancers (1).However, many human cancer researchers doubt that a mammary tumor virus is involved (2,3). If tumor viruses are involved in human cancers, determining the mode of transmission from mice to humans and/or from human to human is important. It is my opinion, that the evidence for a "human mammary tumor virus" should be based on more than PCR amplification of sequences, as that method is too prone to false...
read full comment
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HPV test is a virology test, not for predicting cancer (Sin Hang Lee, 19 August 2009)
Since Dr. Castle wrote this Commentary from an office in the authoritative National Cancer Institute of the United States (NCI) and the Commentary was published in a peer-reviewed international scientific journal, his opinions will unfortunately influence many health care policy makers whose decisions will in turn affect the welfare of many women worldwide. The undersigned felt obligated to comment on this Commentary.
Under an academic title, the Commentary promotes a generation of less specific HPV tests which may refer more women to unnecessary colposcopic biopsies than the Digene hc2 HPV test due to cross-reactivity with non-target HPV types. The Commentary endorsed these HPV tests “despite the cross-reactivity to these weakly carcinogenic or non-carcinogenic HPV... read full comment
Comment on: Castle Infectious Agents and Cancer, 4:7
Please investigate cytomegalovirus (Carol Thompson, 15 February 2009)
Please investigate cytomegalovirus before concluding that smoking is the cause. For socioeconomic reasons, smokers are more likely to have been infected by this virus, which is known to have powerful immunosuppressive effects.
Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination--an impact of immunosenescence. P Trzonkowski, J Myśliwska, E Szmit, J Wieckiewicz, K Lukaszuk, LB Brydak, M Machała, A Myśliwski. Vaccine 2003 Sep 8;21(25-26):3826-3836. "Non-responders of both ages we characterised by higher levels of anti-CMV IgG and higher percentages of CD57+CD28- lymphocytes (known to be associated with CMV carrier status) together with increased concentrations of... read full comment
Comment on: Giorgi et al. Infectious Agents and Cancer, 3:9
Cancer of Uterine Cervix and Oncological Terrain with Inherited Oncological Real Risk. (Sergio Stagnaro, 11 February 2009)
Editors,I consider artiche conclusion unfortunately erroneously incomplete: The strong association found between HPV infection, specifically types 16 and 18 and cancer of the uterine cervix in Zaragoza, Spain, stresses the importance of ongoing efforts to institute a vaccine program with recently approved HPV vaccines in order to prevent cervical cancer in this population. As a matter of facts, cervix cancer involves exclusively women with Oncological Terrain “and” Inherited Oncolgical Real Risk of cervix. If we administer anti-HPV Vaccine to women without such as predisposition, we lose money, time and energy uselessly(1-10).1) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it... read full comment
Comment on: Bernal et al. Infectious Agents and Cancer, 3:8
Seeking comments on "Human Mammary Tumor Virus" (Brian Foley, 16 November 2006)
There are now dozens of GenBank DNA sequence entries for "Human Mammary Tunor Virus", such as the ones with accession numbers DQ910870 and AF248269. There are also many more, identified as "Mouse Mammary Tumor Virus" from human cancer tissue. Also AF513916 "human betaretrovirus". As well as at least one paper linking the geographical distribution of mice to human breast cancers (1).However, many human cancer researchers doubt that a mammary tumor virus is involved (2,3). If tumor viruses are involved in human cancers, determining the mode of transmission from mice to humans and/or from human to human is important. It is my opinion, that the evidence for a "human mammary tumor virus" should be based on more than PCR amplification of sequences, as that method is too prone to false... read full comment
Comment on: Buonaguro et al. Infectious Agents and Cancer, 1:1